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Despite increases in e-cigarette sales restrictions, support for sales restrictions and perceived impact on young adult use are unclear. We analyzed Feb-May 2020 data from a longitudinal study of 2,159 young adults [...] in 6 metropolitan areas (Atlanta, Boston, Minneapolis, Oklahoma City, San Diego, Seattle). We examined support for e-cigarette sales restrictions and – among e-cigarette users – perceived impact of flavored vape product and all vape product sales restrictions on e-cigarette and cigarette use (and potential correlates; i.e., e-cigarette/tobacco use, use-related symptoms/health concerns).