Researchers discover how cigarette smoke impairs critical lung immune cells

January 31, 2025 by biomelbourne.org

Researchers discover how cigarette smoke impairs critical lung immune cells

Cigarette smoke alters lung immune cells, making smokers more prone to respiratory infections like COPD. Australian researchers found that chemicals in smoke affect MAIT cells, which defend against infections and inflammation. The study suggests smoke weakens immune responses and worsens lung diseases. Collaborative research showed smoke-exposed mice had lung problems and were more vulnerable to influenza. The absence of MAIT cells protected mice from smoke-induced COPD. Understanding the impact of smoke on MAIT cells could lead to improved COPD treatments. Further investigations will explore specific MAIT cell pathways affected by smoke exposure. This study highlights the importance of interdisciplinary science in uncovering smoking-related health risks and potential treatments.


12.50% of the adult population are current smokers. There are approximately 2.6 million current smokers in Australia 14.80% of men are current smokers but only 10.30% of women.
SOURCE: GSTHR

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