Nicotinic acid protects the liver from ischemia-reperfusion injury

January 06, 2026 by news-medical.net

Nicotinic acid protects the liver from ischemia-reperfusion injury

A recent study in Liver Research by Chinese researchers reveals that nicotinic acid, a form of vitamin B3, effectively reduces liver damage from hepatic ischemia-reperfusion injury. This type of injury is common in liver surgery and transplants, leading to oxidative stress and inflammation. Nicotinic acid's protective effects surpass N-acetylcysteine by targeting damaged mitochondria, as shown in experiments on mice and hepatocytes. The treatment not only reduces liver injury markers and inflammation but also enhances mitochondrial quality by promoting mitophagy and mitochondrial biogenesis. With its safety, affordability, and availability, nicotinic acid shows promise for improving outcomes in liver surgery, prompting upcoming human trials.

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