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Few topics in public health and medicine are as contentious as electronic cigarettes (e-cigarettes), a diverse and rapidly evolving array of products that appeared on the consumer market a decade ago. e-Cigarettes are battery-powered devices that heat a solution, typically containing nicotine and other chemicals including flavorings, to produce an aerosol that users inhale or “vape.” e-Cigarettes do not burn tobacco to generate smoke, and it is the many chemicals in tobacco smoke—not the nicotine—that are responsible for the global burden of tobacco-related disease that accounts for an estimated 6 million deaths worldwide [...]