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To mark the annual US Food Drug and Law Institute Tobacco and Nicotine Products Regulation and Policy Conference (21-23 Oct), where FDA traditionally gives an update on its plans for nicotine regulation, I thought it worth noting that the centrepiece of its comprehensive strategy for nicotine seems to have disappeared.   This would be a proposed rule lowering nicotine levels in cigarettes with a view to making them sub-addictive – persuading adults to quit and adolescents to never start.  The trouble is that consumers, markets, producers, and criminal networks have a way of thwarting such bold measures.