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More than 480,000 U.S. deaths per year, as well as diseases affecting 16 million living Americans, can be attributed to cigarette smoking, according to the Centers for Disease Control and Prevention. In particular, this behavior continues to be overrepresented among those with mental illness, substance use disorders, and socioeconomic disadvantage. Led by Stephen T. Higgins, Ph.D., [...] the study sought to determine if reducing the nicotine content of cigarettes decreases smoking rates and nicotine dependence severity among adults with psychiatric disorders or socioeconomic disadvantage.