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A new study of high school seniors in the U.S. suggests that teens who are less satisfied with their lives and seek out risky experiences and exciting, unpredictable friends are more likely to use multiple illicit substances regularly. Teens' attitude toward e-cigarette use also played a critical role in their use of other substances. Students who considered vaping to be a relatively harmless activity were more likely to use significant amounts of tobacco, alcohol, marijuana and other drugs.