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As the pandemic of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still under progression, the identification of prognostic factors is a global challenge. Among epidemiological risk factors, the role of smoking, to date, is unclear. Smoking has been initially found associated with adverse disease prognosis of COVID- 19, although this finding remains controversial[. Reported rates of current smokers among SARS-CoV-2-infected patients are heterogeneous, ranging from 1.4% to 12.5% (TABLE [1, 3-10]).