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Northwestern scientists have discovered new mechanisms used by nicotine to manipulate the brain's reward pathway—findings which could inform the development of future anti-addiction therapies. [...] "Identification of the detailed mechanisms by which nicotine alters brain circuitry is a major priority," Drenan said. "We all understand the detrimental effects of cigarettes and other tobacco products. But electronic cigarette usage is also on the rise with adolescents, [...]