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U.S. regulators will soon begin cracking down on vaping companies that are taking advantage of a now-closed loophole, including the maker of a line of fruit-flavored e-cigarettes that have become teenagers’ top choice.

Under a law taking effect Thursday, the Food and Drug Administration can regulate e-cigarettes and similar products that use synthetic nicotine.

The action targets Puff Bar and several other vaping companies that recently switched their formulas to laboratory-made nicotine to skirt FDA oversight.