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Business leaders are floating two of Tasmania's poorest areas for a vaping trial, despite a review for the federal government finding e-cigarettes pose a serious health risk.

The Tasmanian Chamber of Commerce and Industry and the Tasmanian Small Business Council on Thursday said the state's smoking rate of 17.6 per cent was the second highest in the country and new ideas were needed to bring it down. "There is considerable evidence internationally that nicotine vaping and e-cigarettes are not only significantly less harmful than traditional cigarettes, but they are also very effective smoking cessation aids," the organisations said.