The podcast is powerfully contrarian, but not in a trollish sense. Instead, it genuinely challenges listeners to rethink their priors about drug use and drug abuse and the supposed bright lines between “good drugs” (like pot) and “bad drugs” (like opioids). Early guests will include the acclaimed sex-advice columnist Dan Savage; the former president of Colombia, Juan Manuel Santos; and the bearded integrative medicine guru Dr. Andrew Weil, who began his research career at Harvard in the 1960s studying psychoactive drugs.