Smokers attending emergency departments will be given free e-cigarettes and taught how to use them, in a trial designed to help people quit.
Patients will be offered a device, enough e-liquid supplies for a week, and referral to local smoking-cessation services, alongside medical advice.
Hospitals in Norfolk, London, Leicester and Edinburgh will participate.
E-cigarettes are not available on the NHS, other than in trials, but health experts say they can help people quit.