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A new analysis of data from a randomised controlled trial of the stop-smoking drug varenicline (brand name Chantix in the US and Champix elsewhere), has provided clear evidence that varenicline does not increase the risk of psychiatric problems. The study also assessed the risk of psychiatric problems associated with bupropion and the nicotine patch. It similarly found moderate to strong evidence for no increased risk of neuropsychiatric adverse events relative to use of a placebo.